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Arq Bras Endocrinol Metabol. 2011 Nov;55(8):613-21.

Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD).

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  • 1Pediatric Endocrinology Unit, Pediatric Department, Santa Casa de São Paulo Hospital, Brazil. renata-noronha@uol.com.br


Cystic fibrosis (CF) is the most common recessive autosomal disease among Caucasian. Children with CF have benefitted from advances in medical and nutritional treatments, and this can be gleaned from the improvement in the survival of these patients. The increase in the survival rate brought with it the appearance of co-morbidities related to CF. Nowadays cystic fibrosis-related diabetes (CFRD) is considered the most common complication associated with CF. It can appear as early as infancy or adolescence, and its prevalence can be as high as 50% in adult patients. Because of its high prevalence, difficulties in early detection and the risks involved, in recent years several studies and consensuses have focused on this condition, adding information about the epidemiology, pathophysiology, prognosis and treatment of CFRD. The main aspects of these new concepts, as well as the current recommendations for its diagnosis and follow-up, will be presented in this study.

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