Format

Send to:

Choose Destination
See comment in PubMed Commons below
Arch Gen Psychiatry. 2012 Jan;69(1):46-52. doi: 10.1001/archgenpsychiatry.2011.144.

Autism spectrum disorders and autistic like traits: similar etiology in the extreme end and the normal variation.

Author information

  • 1Department of Clinical Sciences, Lund University, Sweden. sebastian.lundstrom@neuro.gu.se

Abstract

CONTEXT:

Autism spectrum disorders (ASDs) have been suggested to represent the extreme end of a normal distribution of autistic like traits (ALTs). However, the evidence of this notion is inconclusive.

OBJECTIVE:

To study whether there are similar genetic and/or environmental etiologies behind ASDs and ALTs.

DESIGN:

A nationwide twin study.

PARTICIPANTS:

Consenting parents of all Swedish twins aged 9 and 12 years, born between July 1, 1992, and December 31, 2001 (n = 19 208), were interviewed by telephone to screen for child psychiatric conditions, including ASDs.

MAIN OUTCOME MEASURES:

Two validated cutoffs for ASDs, 2 cutoffs encompassing the normal variation, and 1 continuous measure of ALTs were used with DeFries-Fulker extreme-end analyses and standard twin study methods.

RESULTS:

We discerned a strong correlation between the 4 cutoffs and the full variation of ALTs. The correlation was primarily affected by genes. We also found that the heritability for the 4 cutoffs was similar.

CONCLUSION:

We demonstrate an etiological similarity between ASDs and ALTs in the normal variation and, with results from previous studies, our data suggest that ASDs and ALTs are etiologically linked.

PMID:
22213788
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk