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Anticancer Res. 2012 Jan;32(1):223-36.

Ecological studies of the UVB-vitamin D-cancer hypothesis.

Author information

  • Sunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA 94164-1603, USA. wbgrant@infionline.net

Abstract

BACKGROUND/AIM:

This paper reviews ecological studies of the ultraviolet-B (UVB)-vitamin D-cancer hypothesis based on geographical variation of cancer incidence and/or mortality rates.

MATERIALS AND METHODS:

The review is based largely on three ecological studies of cancer rates from the United States; one each from Australia, China, France, Japan, and Spain; and eight multicountry, multifactorial studies of cancer incidence rates from more than 100 countries.

RESULTS:

This review consistently found strong inverse correlations with solar UVB for 15 types of cancer: bladder, breast, cervical, colon, endometrial, esophageal, gastric, lung, ovarian, pancreatic, rectal, renal, and vulvar cancer; and Hodgkin's and non-Hodgkin's lymphoma. Weaker evidence exists for nine other types of cancer: brain, gallbladder, laryngeal, oral/pharyngeal, prostate, and thyroid cancer; leukemia; melanoma; and multiple myeloma.

CONCLUSION:

The evidence for the UVB-vitamin D-cancer hypothesis is very strong in general and for many types of cancer in particular.

PMID:
22213311
[PubMed - indexed for MEDLINE]
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