Ruthenium catalyzed synthesis of enaminones

Naga Durgarao Koduri; Halee Scott; Bethany Hileman; Justin D Cox; Michael Coffin; Lindsay Glicksberg; Syed R Hussaini

doi:10.1021/ol202812d

Ruthenium catalyzed synthesis of enaminones

Org Lett. 2012 Jan 20;14(2):440-3. doi: 10.1021/ol202812d. Epub 2011 Dec 29.

Authors

Naga Durgarao Koduri¹, Halee Scott, Bethany Hileman, Justin D Cox, Michael Coffin, Lindsay Glicksberg, Syed R Hussaini

Affiliation

¹ Department of Chemistry and Biochemistry, The University of Tulsa, Keplinger Hall, 800 South Tucker Drive, Tulsa, Oklahoma 74101, USA.

PMID: 22208907
DOI: 10.1021/ol202812d

Abstract

The Grubbs first-generation catalyst has been found to be an effective catalyst for the synthesis of enaminones by coupling thioamides with α-diazodicarbonyl compounds. The reaction is successful in converting primary, secondary, and tertiary thioamides into their corresponding enaminones. The reaction is also suitable for the synthesis of chiral enaminones.