Am J Hum Genet. 1990 Nov;47(5):860-6.

Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.

Sanal O, Wei S, Foroud T, Malhotra U, Concannon P, Charmley P, Salser W, Lange K, Gatti RA.

Source

Department of Pathology, University of California, Los Angeles 90024.

Abstract

We recently mapped the gene for ataxia-telangiectasia group A (ATA) to chromosome 11q22-23 by linkage analysis, using the genetic markers THY1 and pYNB3.12 (D11S144). The most likely order was cent-AT-S144-THY1. The present paper describes further mapping of the AT locus by means of a panel of 10 markers that span approximately 60 cM in the 11q22-23 region centered around S144 and THY1. Location scores indicate that three contiguous subsegments within the [S144-THY1] segment, as well as three contiguous segments telomeric to THY1, are each unlikely to contain the AT locus, while the more centromeric [STMY-S144] segment is most likely to contain the AT locus. These data, together with recent refinements in the linkage and physical maps of 11q22-23, place the AT locus at 11q23.

PMID:: 2220826; [PubMed - indexed for MEDLINE]
PMCID:: PMC1683694

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Genetic Markers

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

The ataxia-telangiectasia gene (ATA) on chromosome II is distinct from the ETS-1 gene. [Am J Hum Genet. 1990]
The ataxia-telangiectasia gene (ATA) on chromosome II is distinct from the ETS-1 gene.
Concannon P, Malhotra U, Charmley P, Reynolds J, Lange K, Gatti RA. Am J Hum Genet. 1990 Apr; 46(4):789-94.
Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus. [Cancer Genet Cytogenet. 1990]
Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus.
Wei S, Rocchi M, Archidiacono N, Sacchi N, Romeo G, Gatti RA. Cancer Genet Cytogenet. 1990 May; 46(1):1-8.
Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22. [Nucleic Acids Res. 1990]
Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.
McConville CM, Formstone CJ, Hernandez D, Thick J, Taylor AM. Nucleic Acids Res. 1990 Aug 11; 18(15):4335-43.
Review Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome 11q22-q23. [Int J Radiat Biol. 1994]
Review Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome 11q22-q23.
McConville CM, Byrd PJ, Ambrose HJ, Taylor AM. Int J Radiat Biol. 1994 Dec; 66(6 Suppl):S45-56.
Review Physical map of the region surrounding the ataxia-telangiectasia gene on human chromosome 11q22-23. [Neuropediatrics. 1999]
Review Physical map of the region surrounding the ataxia-telangiectasia gene on human chromosome 11q22-23.
Udar NS, Xu S, Bay JO, Dandekar SS, Patel N, Chen X, Liang TY, Uhrhammer N, Klisak I, Shizuya H, et al. Neuropediatrics. 1999 Aug; 30(4):176-80.

See reviews... See all...

Cited by 9 PubMed Central articles

Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer. [Am J Hum Genet. 1995]
Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.
Jongmans W, Verhaegh GW, Jaspers NG, Oshimura M, Stanbridge EJ, Lohman PH, Zdzienicka MZ. Am J Hum Genet. 1995 Feb; 56(2):438-43.
Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium. [Am J Hum Genet. 1995]
Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.
Lange E, Borresen AL, Chen X, Chessa L, Chiplunkar S, Concannon P, Dandekar S, Gerken S, Lange K, Liang T. Am J Hum Genet. 1995 Jul; 57(1):112-9.
Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families. [Am J Hum Genet. 1995]
Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families.
Uhrhammer N, Lange E, Porras O, Naeim A, Chen X, Sheikhavandi S, Chiplunkar S, Yang L, Dandekar S, Liang T. Am J Hum Genet. 1995 Jul; 57(1):103-11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
UniSTS
Genetic, physical, and sequence mapping reagents in the UniSTS database associated with the current articles through references on sequence tagged site (STS) submissions as well as automated searching of PubMed abstracts and full-text PubMed Central articles for marker names.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region...
Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.
Am J Hum Genet. 1990 Nov ;47(5):860-6.

PubMed
Congenital dyserythropoietic anemia type II: molecular analysis and expression o...
Congenital dyserythropoietic anemia type II: molecular analysis and expression of the SEC23B gene.
Orphanet J Rare Dis. 2011 Dec 30 ;6:89.

PubMed
Chromosomal localization of the human alpha-L-iduronidase gene (IDUA) to 4p16.3.
Chromosomal localization of the human alpha-L-iduronidase gene (IDUA) to 4p16.3.
Am J Hum Genet. 1990 Nov ;47(5):802-7.

PubMed
Sodium nitroprusside enhanced cardiopulmonary resuscitation prevents post-resusc...
Sodium nitroprusside enhanced cardiopulmonary resuscitation prevents post-resuscitation left ventricular dysfunction and improves 24-hour survival and neurological function in a porcine model of prolonged untreated ventricular fibrillation.
Resuscitation. 2011 Dec ;82 Suppl 2:S35-40.

PubMed
Frequency of three Hex A mutant alleles among Jewish and non-Jewish carriers ide...
Frequency of three Hex A mutant alleles among Jewish and non-Jewish carriers identified in a Tay-Sachs screening program.
Am J Hum Genet. 1990 Oct ;47(4):698-705.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: