J Clin Microbiol. 2012 Mar;50(3):1014-8. Epub 2012 Jan 11.

Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.

Sitaraman R, Israel DA, Romero-Gallo J, Peek RM Jr.

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Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Abstract

Pathogenic Helicobacter pylori strains can selectively activate epithelial mitogen-activated protein kinase (MAPK) signaling pathways linked with disease. We now demonstrate that H. pylori-induced hemolysis is strain specific and is mediated by phospholipases PldA1 and PldD. Inactivation of PldD inhibited activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), indicating that H. pylori hemolytic phospholipases also harbor MAPK-activating properties.

PMID:: 22205825; [PubMed - indexed for MEDLINE]
PMCID:: PMC3295145; [Available on 2012/9/1]

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