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Clin Pharmacol Ther. 2012 Feb;91(2):310-4. doi: 10.1038/clpt.2011.282. Epub 2011 Dec 28.

The epigenetic code in depression: implications for treatment.

Author information

  • 1Department of Psychiatry, Psychosomatic Medicine & Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany. marc.schroeder@kgu.de

Abstract

Major depressive disorder (MDD) is a common and disabling disorder that carries both a substantial personal burden as well as a social one. A better understanding of the epigenetic mechanisms in depression might provide a new framework for individually tailored pharmacologic treatment options. In this review we highlight current knowledge about the role of epigenetic mechanisms in the pathogenesis of depression and treatment implications.

PMID:
22205200
[PubMed - indexed for MEDLINE]
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