Curr Infect Dis Rep. 2012 Feb;14(1):102-9.

Key Concepts in the Early Immunology of HIV-1 Infection.

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, 1735 W. Harrison St. Cohn Research Building, Chicago, IL, 60612, USA, basile_siewe@rush.edu.

Abstract

Though HIV-1 is a sexually transmitted infection, the gut associated lymphoid tissue (GALT) that houses about 60% of the body's total immune cells is unequivocally the earliest and most important target of HIV-1. In this review we summarize recent data regarding the early events in HIV-1 pathogenesis, with special emphasis on pathogenic effects on the GALT.

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