Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Pediatrics. 2012 Jan;129(1):45-54. doi: 10.1542/peds.2011-0249. Epub 2011 Dec 26.

Parental smoking and vascular damage in their 5-year-old children.

Author information

  • 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Abstract

BACKGROUND:

The relation between smoke exposure in early life, the prenatal period in particular, and the vascular development of young children is largely unknown.

METHODS:

Data from the birth cohort participating in the WHISTLER-Cardio study were used to relate the smoking of parents during pregnancy to subsequent vascular properties in their children. In 259 participating children who turned 5 years of age, parental smoking data were updated and children's carotid artery intima-media thickness (CIMT) and arterial wall distensibility were measured by using ultrasonography.

RESULTS:

Children of mothers who had smoked throughout pregnancy had 18.8 μm thicker CIMT (95% confidence interval [CI] 1.1, 36.5, P = .04) and 15% lower distensibility (95% CI -0.3, -0.02, P = .02) after adjustment for child's age, maternal age, gender, and breastfeeding. The associations were not found in children of mothers who had not smoked in pregnancy but had smoked thereafter. The associations were strongest if both parents had smoked during pregnancy, with 27.7 μm thicker CIMT (95% CI 0.2, 55.3) and 21% lower distensibility (95% CI -0.4, -0.03).

CONCLUSION:

Exposure of children to parental tobacco smoke during pregnancy affects their arterial structure and function in early life.

Comment in

PMID:
22201150
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk