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J Exp Med. 2012 Jan 16;209(1):19-27. doi: 10.1084/jem.20112084. Epub 2011 Dec 26.

ZBTB1 is a determinant of lymphoid development.

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  • 1Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

PMID:
22201126
[PubMed - indexed for MEDLINE]
PMCID:
PMC3260866
Free PMC Article
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