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    Brain Dev. 2011 Dec 23. [Epub ahead of print]

    A case of malignant migrating partial seizures in infancy as a continuum of infantile epileptic encephalopathy.

    Lee EH, Yum MS, Jeong MH, Lee KY, Ko TS.

    Source

    Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

    Abstract

    The syndrome of malignant migrating partial seizures in infancy (MMPSI) is characterized by onset before the age of 6months, nearly continuous electrographic seizures involving multiple independent areas of onset in both hemispheres, and poor developmental outcome. This report presents a case involving a patient with MMPSI, who later developed West syndrome. At the age of 2months old, he showed multifocal partial seizures, which were refractory to antiepileptic drugs. His electroencephalogram (EEG) revealed characteristic migrating multifocal epileptiform activities and neuroimaging finding was normal. The focal seizures were refractory to antiepileptic drugs and ketogenic diet. When he was 9months old, epilepic spasms were observed with hypsarrhythmia on EEG. He also showed severe developmental delay. MMPSI may be a continuum of infantile epileptic encephalpathy and could evolve to West syndrome.

    Copyright © 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

    PMID:
    22197566
    [PubMed - as supplied by publisher]

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