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Ophthalmology. 2012 Apr;119(4):765-70. doi: 10.1016/j.ophtha.2011.09.044. Epub 2011 Dec 23.

Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis.

Author information

  • 1Department of Cardiology, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA. antoinefernandezt@hotmail.com

Abstract

OBJECTIVE:

To determine whether age-related macular degeneration (AMD) is a risk indicator for coronary heart disease (CHD) and cardiovascular disease (CVD) events independent of other known risk factors in a multi-ethnic cohort.

DESIGN:

Population-based prospective cohort study.

PARTICIPANTS:

A diverse population sample of 6233 men and women aged 45 to 84 years without known CVD from the Multi-Ethnic Study of Atherosclerosis (MESA).

METHODS:

Participants in the MESA had retinal photographs taken between 2002 and 2003. Photographs were evaluated for AMD. Incident CHD and CVD events were ascertained during clinical follow-up visits for up to 8 years after the retinal images were taken.

MAIN OUTCOME MEASURES:

Incident CHD and CVD events.

RESULTS:

Of the 6814 persons at risk of CHD, there were 893 participants with early AMD (13.1%) and 27 patients (0.5%) at baseline. Over a mean follow-up period of 5.4 years, there was no statistically significant difference in incident CHD or CVD between the AMD and non-AMD groups (5.0% vs. 3.9%, P = 0.13 for CHD and 6.6% vs. 5.5%, P = 0.19 for CVD). In Cox regression models adjusting for CVD risk factors, there was no significant relationship between presence of any AMD and any CHD/CVD events (hazard ratio 0.99; 95% confidence interval, 0.74-1.33; P = 0.97). No significant association was found between subgroups of early AMD or late AMD and incident CHD/CVD events.

CONCLUSIONS:

In persons without a history of CVD, AMD was not associated with an increased risk of CHD or CVD.

Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

PMID:
22197438
[PubMed - indexed for MEDLINE]
PMCID:
PMC3314126
Free PMC Article
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