Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nano Lett. 2012 Jan 11;12(1):203-8. doi: 10.1021/nl203334c. Epub 2011 Dec 28.

Polymeric nanomaterials for islet targeting and immunotherapeutic delivery.

Author information

  • 1Vascular Biology Program, Departments of Pathology and Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.

© 2011 American Chemical Society

PMID:
22196766
[PubMed - indexed for MEDLINE]
PMCID:
PMC3280082
Free PMC Article

Images from this publication.See all images (5)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Write to the Help Desk