Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2011 Dec 23;147(7):1438-9. doi: 10.1016/j.cell.2011.12.002.

Transcription and mRNA stability: parental guidance suggested.

Author information

  • 1Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.


The level of an mRNA within a cell depends on both its rate of synthesis and rate of decay. Now, independent studies by Bregman et al. and Trcek et al. provide evidence that these two processes are integrated. They show that transcription factors and DNA promoters can directly influence the relative stability of transcripts that they produce.

Copyright © 2011 Elsevier Inc. All rights reserved.

Free full text

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk