Appl Radiat Isot. 2012 Apr;70(4):676-80. Epub 2011 Dec 7.

Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino acid PET tracer.

Sun T, Tang G, Tian H, Wang X, Chen X, Chen Z, Wang S.

Source

Department of Cardiac Function, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China. beibeisun2008@163.com

Abstract

(18)F labeled natural amino acids have been introduced as promising tumor imaging agents. A novel [(18)F]fluoro amino acid analog 1-[(18)F]fluoroethyl-L-tryptophan (1-[(18)F]FETrp) was designed and synthesized by a two-pot three-step procedure, including the synthesis of 1-[(18)F]fluoro-2- (tosyloxy)ethane, the [(18)F]fluoroethylation of the precursor N-Boc-L-tryptophan ethyl ester and following the deprotection of the tert-butoxycarbonyl and ethyl ester protecting groups. 1-[(18)F]FETrp was resulted in 0.9 ± 0.2% (n=5) radiochemical yields (no decay corrected) by HPLC purification, within a total synthesis time of 65 min. The radiochemical purity of 1-[(18)F]FETrp was 95-97%. The radiosynthetic method needs to be further optimized to get a satisfying radiochemical yield.

PMID:: 22196677; [PubMed - in process]

Publication Types

Research Support, Non-U.S. Gov't

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Synthesis of [¹¹C]PBR06 and [¹⁸F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO). [Steroids. 2011]
Synthesis of [¹¹C]PBR06 and [¹⁸F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO).
Wang M, Gao M, Miller KD, Zheng QH. Steroids. 2011 Nov; 76(12):1331-40. Epub 2011 Jul 3.
Three-step, "one-pot" radiosynthesis of 6-fluoro-3,4-dihydroxy-L-phenylalanine by isotopic exchange. [J Nucl Med. 2009]
Three-step, "one-pot" radiosynthesis of 6-fluoro-3,4-dihydroxy-L-phenylalanine by isotopic exchange.
Wagner FM, Ermert J, Coenen HH. J Nucl Med. 2009 Oct; 50(10):1724-9. Epub 2009 Sep 16.
1-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione: design, synthesis, and radiosynthesis of a new [18F]fluoropyridine-based maleimide reagent for the labeling of peptides and proteins. [Bioconjug Chem. 2005]
1-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione: design, synthesis, and radiosynthesis of a new [18F]fluoropyridine-based maleimide reagent for the labeling of peptides and proteins.
de Bruin B, Kuhnast B, Hinnen F, Yaouancq L, Amessou M, Johannes L, Samson A, Boisgard R, Tavitian B, Dollé F. Bioconjug Chem. 2005 Mar-Apr; 16(2):406-20.
Fully automated one-pot radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine on the TracerLab FX(FN) module. [Nucl Med Biol. 2011]
Fully automated one-pot radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine on the TracerLab FX(FN) module.
Bourdier T, Greguric I, Roselt P, Jackson T, Faragalla J, Katsifis A. Nucl Med Biol. 2011 Jul; 38(5):645-51. Epub 2011 Mar 3.
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base. [Bioorg Med Chem. 2008]
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
Krasikova RN, Kuznetsova OF, Fedorova OS, Maleev VI, Saveleva TF, Belokon YN. Bioorg Med Chem. 2008 May 1; 16(9):4994-5003. Epub 2008 Mar 17.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino aci...
Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino acid PET tracer.
Appl Radiat Isot. 2012 Apr ;70(4):676-80. Epub 2011 Dec 7 .

PubMed
Bicortical fixation of medial malleolar fractures: a review of 23 cases at risk ...
Bicortical fixation of medial malleolar fractures: a review of 23 cases at risk for complicated bone healing.
J Foot Ankle Surg. 2012 Jan-Feb ;51(1):39-44.

PubMed
Uterine artery embolization complicated by uterine perforation at the site of pr...
Uterine artery embolization complicated by uterine perforation at the site of previous myomectomy.
J Minim Invasive Gynecol. 2012 Jan-Feb ;19(1):128-30.

PubMed
Single polypoid cystitis cystica and glandularis presenting as benign bladder tu...
Single polypoid cystitis cystica and glandularis presenting as benign bladder tumor.
Urology. 1990 Oct ;36(4):364-6.

PubMed
SAGA function in tissue-specific gene expression.
SAGA function in tissue-specific gene expression.
Trends Cell Biol. 2012 Apr ;22(4):177-84. Epub 2011 Dec 21 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino acid PET tracer.

Source

Abstract

Publication Types

Publication Types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information