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Immunity. 2011 Dec 23;35(6):845-6. doi: 10.1016/j.immuni.2011.12.001.

T cell Myc-tabolism.

Author information

  • 1Department of Pharmacology and Cancer Biology, Department of Immunology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, USA. jeff.rathmell@duke.edu

Abstract

T cell activation leads to a dramatic demand for energy and biosynthetic precursors that is met by increased glucose and glutamine metabolism. In this issue of Immunity, Wang et al. (2011) show that Myc is essential in T cell metabolic reprogramming.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
22195738
[PubMed]
PMCID:
PMC3267318
Free PMC Article
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