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PLoS One. 2011;6(12):e27865. doi: 10.1371/journal.pone.0027865. Epub 2011 Dec 14.

A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.

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  • 1Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America.

Abstract

Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For Alzheimer's disease (AD), the focus is the amyloid beta peptide (Aß) that mediates familial Alzheimer's disease pathology. However, given that age is the greatest risk factor for AD, we explored an alternative drug discovery scheme that is based upon efficacy in multiple cell culture models of age-associated pathologies rather than exclusively amyloid metabolism. Using this approach, we identified an exceptionally potent, orally active, neurotrophic molecule that facilitates memory in normal rodents, and prevents the loss of synaptic proteins and cognitive decline in a transgenic AD mouse model.

PMID:
22194796
[PubMed - indexed for MEDLINE]
PMCID:
PMC3237323
Free PMC Article
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