My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    Int J Radiat Biol. 2012 Apr;88(4):296-310. doi: 10.3109/09553002.2012.652726. Epub 2012 Feb 9.

    A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute.

    Singh VK, Ducey EJ, Brown DS, Whitnall MH.

    Source

    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA. singh@afrri.usuhs.mil

    Abstract

    PURPOSE: The hazard of exposure to ionizing radiation is a serious public and military health concern that has justified substantial efforts to develop medically effective radiation countermeasure approaches, including radiation protectors, mitigators, and therapeutics. Although such efforts were initiated more than half a century ago, no safe and effective radiation countermeasure has been approved by the United States Food and Drug Administration (FDA) for the acute radiation syndrome. This situation has prompted intensified research among government laboratories, academic institutions, and pharmaceutical companies to identify a new generation of countermeasures. In this communication we discuss selected promising radiation countermeasures at advanced stages of development. CONCLUSION: Other than granulocyte colony-stimulating factor, which has an Emergency Use Investigational New Drug (IND) status, four countermeasures have FDA IND status and other promising countermeasures are in development. Here we review primarily the in vivo efficacy of selected countermeasures in animal models and clinical studies.

    PMID:
    22191567
    [PubMed - indexed for MEDLINE]

    Publication Types, MeSH Terms

    Publication Types

    MeSH Terms

    LinkOut - more resources

    Full Text Sources

    Other Literature Sources

      Supplemental Content

      Icon for Informa Healthcare

      Save items

      loading

      Related citations in PubMed

      See reviews... See all...

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk