Format

Send to

Choose Destination
See comment in PubMed Commons below
Acta Anaesthesiol Scand. 2012 May;56(5):655-62. doi: 10.1111/j.1399-6576.2011.02609.x. Epub 2011 Dec 23.

The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study.

Author information

  • 1Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Bispebjerg, Denmark. mortenhylander@gmail.com

Abstract

BACKGROUND:

Accurate and early identification of high-risk surgical patients with perforated peptic ulcer (PPU) is important for triage and risk stratification. The objective of the present study was to develop a new and improved clinical rule to predict mortality in patients following surgical treatment for PPU.

METHODS:

DESIGN:

nationwide cohort study based on prospectively collected data.

SETTING:

thirty-five hospitals in Denmark.

PATIENTS:

a total of 2668 patients surgically treated for gastric or duodenal PPU between 1 February 2003 and 31 August 2009.

OUTCOME MEASURE:

30-day mortality.

RESULTS:

We derived a new clinical prediction rule for 30-day mortality and evaluated and compared its prognostic performance with the American Society of Anaesthesiologists (ASA) and Boey scores. A total of 708 patients (27%) died within 30 days of surgery. The Peptic Ulcer Perforation (PULP) score - comprised eight variables with an adjusted odds ratio of more than 1.28: 1) age > 65 years, 2) active malignant disease or AIDS, 3) liver cirrhosis, 4) steroid use, 5) time from perforation to admission > 24 h, 6) pre-operative shock, 7) serum creatinine > 130 μM, and 8) the four levels of the ASA score (from 2 to 5). The score predicted mortality well (area under receiver operating characteristics curve (AUC) 0.83). It performed considerably better than the Boey score (AUC 0.70) and better than the ASA score alone (AUC 0.78).

CONCLUSION:

The PULP score accurately predicts 30-day mortality in patients operated for PPU and can assist in risk stratification and triage.

© 2011 The Authors Acta Anaesthesiologica Scandinavica © 2011 The Acta Anaesthesiologica Scandinavica Foundation.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk