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Clin Vaccine Immunol. 2012 Feb;19(2):284-7. doi: 10.1128/CVI.05592-11. Epub 2011 Dec 21.

Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus.

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  • 1Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA.


A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV (n = 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test, P = 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.

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