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Int J Cardiol. 2013 Jul 15;167(1):63-6. doi: 10.1016/j.ijcard.2011.11.082. Epub 2011 Dec 20.

Circulating miR-423_5p fails as a biomarker for systemic ventricular function in adults after atrial repair for transposition of the great arteries.

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  • 1Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany. otutarel@hotmail.com

Abstract

BACKGROUND:

Recently, the microRNA miR-423_5p was identified as a biomarker for left ventricular heart failure. Its role in patients with a systemic right ventricle and reduced ejection fraction after atrial repair for transposition of the great arteries has not been evaluated.

METHODS:

In 41 patients and 10 age- and sex-matched healthy controls circulating miR-423_5p concentration was measured and correlated to clinical parameters, cardiac functional parameters assessed by magnetic resonance imaging, and cardiopulmonary exercise testing.

RESULTS:

Levels of circulating miR-423_5p showed no difference between patients and controls. Further, there was no correlation between miR-423_5p and parameters of cardiopulmonary exercise testing or imaging findings.

CONCLUSIONS:

In patients with a systemic right ventricle and reduced ejection fraction miR-423_5p levels are not elevated. Therefore, circulating miR-423_5p is not a useful biomarker for heart failure in this patient group.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
22188991
[PubMed - indexed for MEDLINE]
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