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    Rev Med Suisse. 2011 Nov 2;7(315):2142, 2144-5.

    [Contribution of the CoLaus study to decipher the determinants of serum uric acid].

    [Article in French]
    Bochud M, Vollenweider P, Waeber G.

    Source

    Institut de médecine sociale et préventive, CHUV, Route de la Corniche 2, 1066 Epalinges. Murielle.Bochud@chuv.ch

    Abstract

    Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.

    PMID:
    22187784
    [PubMed - indexed for MEDLINE]

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