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Exp Clin Endocrinol Diabetes. 2012 Apr;120(4):217-23. doi: 10.1055/s-0031-1297969. Epub 2011 Dec 20.

Diabetes mellitus and incidence and mortality of gastric cancer: a meta-analysis.

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  • 1Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, China.

Abstract

AIMS:

Epidemiologic studies have examined the possible associations between diabetes mellitus (DM) and gastric cancer (GC), but the results are inconclusive. We conducted a meta-analysis to assess the evidence regarding the associations between diabetes and incidences of, or mortality from, gastric cancer.

METHODS:

PubMed, Embase and Web of Science were searched up to Oct 20, 2011. We identified studies that included effects estimates with 95% confidence intervals (CIs) of the associations between GC and diabetes. Summary RRs for the GC incidence and mortality were calculated using random-effects model; subgroup analyses were also performed. Heterogeneity among studies was examined using Q and I2 statistics.

RESULTS:

A total of 7 case-control and 18 cohort studies met the inclusion criteria. The summary RR showed a slightly statistical link between history of DM and GC incidence (RR=1.11, 95% CI: 1.00-1.24, p=0.045, I2=79.5%). In the subgroup analyses, a positive association was noted among the studies conducted in Asia (summary RR=1.19, 95% CI: 1.07-1.32, I2=29.8%). Additionally, slight associations between DM and GC were observed by pooling the data of type 2 DM, cohort studies and the studies controlling more confounders, respectively. Furthermore, mortality from GC with diabetes was increased compared with individuals without diabetes (summary RR=1.29, 95% CI: 1.04-1.59). No publication bias was found.

CONCLUSION:

Individuals with diabetes have an increased risk of developing gastric cancer, and are positively associated with gastric cancer mortality. Large better-designed cohort studies are needed to verify this conclusion.

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

PMID:
22187293
[PubMed - indexed for MEDLINE]
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