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Stat Med. 1990 Jul;9(7):803-9.

A Markovian model for comparing incidences of side effects.

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  • 1CIBA-GEIGY Corporation, Summit, New Jersey 07901.


For clinical trials that entail observations at successive visits for the occurrence of a side effect, this paper considers a likelihood-based method to compare side effect incidence rates. The method, which employs the assumption of a Markov chain of order one for the vectors of binary responses, handles missing data due to premature withdrawals. An actual numerical example and a simulated example illustrate the technique.

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