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Pediatr Blood Cancer. 2012 Jul 15;59(1):126-32. doi: 10.1002/pbc.24017. Epub 2011 Dec 16.

Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort.

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  • 1Division of Pediatric Hematology, Oncology and BMT, Helen DeVos Children's Hospital, Grand Rapids, Michigan 49503, USA. beth.kurt@devoschildrens.org

Abstract

BACKGROUND:

Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population.

PROCEDURE:

The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self-reported hospitalizations from 10,366 survivors (diagnosed 1970-1986) were compared to U.S. population rates using age- and sex-stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment-related risk factors with hospitalization were investigated.

RESULTS:

Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13-32) and 28.6 years of age (SD: 7.7, range: 13-51). Survivor hospitalization rates were 1.6 times the U.S. population (95% CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow-up and cancer diagnosis, with highest SIRs noted among male (SIR = 2.6, 95% CI: 2.2; 3.0) and female (SIR = 2.7, 95% CI: 2.4; 3.1) survivors aged 45-54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non-obstetrical hospitalization.

CONCLUSIONS:

Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment-related complications as this population ages.

Copyright © 2011 Wiley Periodicals, Inc.

PMID:
22180128
[PubMed - indexed for MEDLINE]
PMCID:
PMC3359936
Free PMC Article

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