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Opt Lett. 2011 Dec 15;36(24):4800-2. doi: 10.1364/OL.36.004800.

Multiscale multimodal imaging with multiphoton microscopy and optical coherence tomography.

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  • 1Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada.


A multiscale multiphoton microscopy (MPM) and optical coherence tomography (OCT) system has been developed using a sub-10 fs Ti:sapphire laser. The system performs cross-sectional OCT imaging over millimeter field-of-view and en-face high-resolution MPM imaging with submicrometer resolution from the same sample location. With fish cornea, we have demonstrated cross-sectional imaging of cornea tissue layers using OCT, and the zoom-in imaging of cells and collagen fibers in each layer using MPM. The multiscale MPM/OCT system shows the potential of a rapid coarse scan to search for abnormal regions and the subsequent fine zoom-in imaging for diagnosis.

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