Format

Send to:

Choose Destination
See comment in PubMed Commons below
Thromb Res. 2012 Mar;129(3):220-4. doi: 10.1016/j.thromres.2011.11.036. Epub 2011 Dec 16.

Platelets and primary haemostasis.

Author information

  • 1Department of Haematology, Inselspital, University of Berne, CH-3010 Berne, Switzerland. clemetson@tki.unibe.ch

Abstract

Platelets have a critical role in haemostasis when vessel wall is injured. Platelet receptors are involved in sequence in this process by slowing platelets down via GPIb/von Willebrand factor to bring them into contact with exposed collagen, then activating them via GPVI to release granule contents and express integrins in a matrix protein binding state. More platelets are incorporated into the growing thrombus and a series of events are set off that finishes with the exposed subendothelium protected by a non-thrombogenic platelet surface and tissue repair underway and the blood flow through the vessel maintained. GPIb is also involved in thrombin activation and, together with GPVI, in the formation of COAT platelets. In thrombosis, pathological changes occur that may lead to life-threatening blockage of vessels. Prevention of thrombosis while maintaining haemostasis remains a major goal of medical research.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22178577
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk