Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 2012 Mar;37(3):85-91. doi: 10.1016/j.tibs.2011.11.004. Epub 2011 Dec 16.

Mitochondrial protein import: from transport pathways to an integrated network.

Author information

  • 1Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, 79104 Freiburg, Germany.

Abstract

Mitochondria, the powerhouses of the cell, import most of their proteins from the cytosol. It was originally assumed that mitochondria imported precursor proteins via a general pathway but recent studies have revealed a remarkable variety of import pathways and mechanisms. Currently, five different protein import pathways can be distinguished. However, the import machineries cooperate with each other and are connected to other systems that function in the respiratory chain, mitochondrial membrane organization, protein quality control and endoplasmic reticulum-mitochondria junctions. In this Opinion, we propose that mitochondrial protein import should not be seen as an independent task of the organelle and that a network of cooperating machineries is responsible for major mitochondrial functions.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22178138
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk