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Appetite. 2012 Apr;58(2):504-7. doi: 10.1016/j.appet.2011.12.001. Epub 2011 Dec 8.

Amygdala response to sucrose consumption is inversely related to artificial sweetener use.

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  • 1Interdepartmental Neuroscience Program, Yale University, SHM L-200, New Haven, CT 06520, USA.

Abstract

Controversy exists over whether exposure to artificial sweeteners degrades the predictive relationship between sweet taste and its post-ingestive consequences. Here we tested whether brain response to caloric sucrose is influenced by individual differences in self-reported artificial sweetener use. Twenty-six subjects participated in fMRI scanning while consuming sucrose solutions. A negative correlation between artificial sweetener use and amygdala response to sucrose ingestion was observed. This finding supports the hypothesis that artificial sweetener use may be associated with brain changes that could influence eating behavior.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22178008
[PubMed - indexed for MEDLINE]
PMCID:
PMC3289048
Free PMC Article
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