Virology. 2012 Feb 5;423(1):38-48. Epub 2011 Dec 15.

NRIP enhances HPV gene expression via interaction with either GR or E2.

Chang SW, Lu PY, Guo JH, Tsai TC, Tsao YP, Chen SL.

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Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Abstract

We previously identified a gene, nuclear receptor-interaction protein (NRIP), which functions as a transcription cofactor in glucocorticoid receptor (GR) and human papillomavirus E2 (HPV E2)-driven gene expression. Here, we comprehensively evaluated the role of NRIP in HPV-16 gene expression. NRIP acts as a transcription cofactor to enhance GR-regulated HPV-16 gene expression in the presence of hormone. NRIP also can form complex with E2 that caused NRIP-induced HPV gene expression via E2-binding sites in a hormone-independent manner. Furthermore, NRIP can associate with GR and E2 to form tri-protein complex to activate HPV gene expression via GRE, not the E2-binding site, in a hormone-dependent manner. These results indicate that NRIP and GR are viral E2-binding proteins and that NRIP regulates HPV gene expression via GRE and/or E2 binding site in the HPV promoter in a hormone-dependent or independent manner, respectively.

PMID:: 22177699; [PubMed - indexed for MEDLINE]

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