Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Functional MR Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna Institute of Neurological Sciences, University of Bologna Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy.
Background and purpose: The aim of this study was to evaluate the presence of abnormalities in the brain of patients with restless legs syndrome (RLS) using voxel-based morphometry and diffusion tensor imaging (DTI). Methods: Twenty patients and twenty controls were studied. Voxel-based morphometry analysis was performed using statistical parametric mapping (SPM8) and FSL-VBM software tools. For voxel-wise analysis of DTI, tract-based spatial statistics (TBSS) and SPM8 were used. Results: Applying an appropriate threshold of probability, no significant results were found either in comparison or in correlation analyses. Conclusions: Our data argue against clear structural or microstructural abnormalities in the brain of patients with idiopathic RLS, suggesting a prevalent role of functional or metabolic impairment.
© 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on