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    Indian J Nucl Med. 2011 Apr;26(2):96-8.

    FDG-PET findings in fronto-temporal dementia: A case report and review of literature.

    Harisankar CN, Mittal BR, Agrawal KL, Abrar ML, Bhattacharya A, Singh B, Modi M.

    Source

    Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

    Abstract

    Fronto-temporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous syndrome, characterized by progressive decline in behavior or language associated with degeneration of the frontal and anterior temporal lobes. Three distinct clinical variants of FTLD have been described. Despite the difficulties, accurate diagnosis is critical because the clinical management differs for Alzheimer's disease (AD) and FTLD. Positron emission tomography with fluro-deoxy-glucose (FDG-PET) typically shows sufficient abnormalities that can be used to improve the accuracy of distinguishing AD from FTLD in individual cases. Though temporo-parietal hypometabolism is sensitive in diagnosis of AD, it is less specific. The importance of evaluating the cingulate and anterior temporal cortices for arriving at a diagnosis of FTLD is stressed.

    PMID:
    22174516
    [PubMed - in process]
    PMCID:
    PMC3237227
    Free PMC Article

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