Transplant Proc. 2011 Dec;43(10):4025-8.

Case report of a successful liver transplantation for acute liver failure due to mitochondrial respiratory chain complex III deficiency.

Iwama I, Baba Y, Kagimoto S, Kishimoto H, Kasahara M, Murayama K, Shimizu K.

Source

Division of General Pediatrics, Saitama Children's Medical Center, Saitama, Japan. iwam.itaru@pref.saitama.lg.jp

Abstract

Mitochondrial respiratory chain disorders can cause acute liver failure in infants and children. Liver transplantation, however, has rarely been indicated for patients with mitochondrial respiratory chain disorders, because of the extrahepatic involvement. Herein we reported a case of acute liver failure with mitochondrial respiratory chain complex III deficiency treated by liver transplantation. At 2 years after transplantation, there were no extrahepatic manifestations. We suggest that mitochondrial disorders should be considered to be a cause of liver failure in infancy and that liver transplantation can be a life-saving treatment.

PMID:: 22172894; [PubMed - indexed for MEDLINE]

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Electron Transport Complex III

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