Proc Natl Acad Sci U S A. 1990 Oct;87(19):7618-22.

Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.

McKeever U, Mordes JP, Greiner DL, Appel MC, Rozing J, Handler ES, Rossini AA.

Source

Department of Medicine, University of Massachusetts Medical School, Worcester 01655.

Abstract

We describe the induction of autoimmune diabetes, insulitis, and thyroiditis in athymic rats following injections of major histocompatibility complex compatible spleen cells. Lymphocytes with these capabilities were found in normal rats of the YOS, WAG, PVG, and diabetes-resistant BB strains, and in diabetes-prone BB rats. Adoptive transfer was facilitated by prior in vivo depletion of RT6.1+ regulatory T cells and in vitro mitogen activation of donor spleen cells. By RT6 depleting diabetes-resistant donors and using nude recipients, transfer of diabetes and thyroiditis was accomplished by using fresh, unstimulated spleen cells. The data suggest that organ-specific autoreactive cells may be present to various degrees but suppressed to a variable extent in many rat strains. The equilibrium between autoreactive and regulatory cells appears to determine the expression of autoimmunity.

PMID:: 2217193; [PubMed - indexed for MEDLINE]
PMCID:: PMC54799

Free PMC Article

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Autoimmune Diseases - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells. [J Autoimmun. 1994]
Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.
Whalen BJ, Greiner DL, Mordes JP, Rossini AA. J Autoimmun. 1994 Dec; 7(6):819-31.
Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat. [Diabetes. 1996]
Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat.
Ellerman KE, Richards CA, Guberski DL, Shek WR, Like AA. Diabetes. 1996 May; 45(5):557-62.
BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes. [Diabetes. 2001]
BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes.
Whalen BJ, Marounek J, Weiser P, Appel MC, Greiner DL, Mordes JP, Rossini AA. Diabetes. 2001 May; 50(5):972-9.
Review The pathogenesis of autoimmune diabetes mellitus. [Curr Opin Immunol. 1989]
Review The pathogenesis of autoimmune diabetes mellitus.
Rossini AA, Mordes JP, Greiner DL. Curr Opin Immunol. 1989-1990 Apr; 2(4):598-603.
Review Autoimmune endocrine diseases. [Year Immunol. 1989]
Review Autoimmune endocrine diseases.
De Baets MH. Year Immunol. 1989; 4:264-75.

See reviews... See all...

Cited by 6 PubMed Central articles

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. [Proc Natl Acad Sci U S A. 2005]
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.
Wan YY, Flavell RA. Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14):5126-31. Epub 2005 Mar 28.
Prevention of insulin-dependent diabetes mellitus--wishful thinking, or reality? [West J Med. 1996]
Prevention of insulin-dependent diabetes mellitus--wishful thinking, or reality?
Palmer J. West J Med. 1996 Mar; 164(3):277-8.
Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats. [Environ Health Perspect. 1993]
Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats.
Kosuda LL, Greiner DL, Bigazzi PE. Environ Health Perspect. 1993 Jun; 101(2):178-85.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.
Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.
Proc Natl Acad Sci U S A. 1990 Oct ;87(19):7618-22.

PubMed
Celivarone for Maintenance of Sinus Rhythm and Conversion of Atrial Fibrillation...
Celivarone for Maintenance of Sinus Rhythm and Conversion of Atrial Fibrillation/Flutter.
J Cardiovasc Electrophysiol. 2012 May;23(5):462-472. doi: 10.1111/j.1540-8167.2011.02234.x. Epub 2011 Dec 15.

PubMed
Testosterone measurement - mandatory in ALL men with ED.
Testosterone measurement - mandatory in ALL men with ED.
Int J Clin Pract. 2012 Jan ;66(1):113; author reply 113-4. doi: 10.1111/j.1742-1241.2011.02801.x.

PubMed
Mushroom poisoning: a personal vignette.
Mushroom poisoning: a personal vignette.
Med J Aust. 2011 Dec 19 ;195(11-12):720-1.

PubMed
The effects of early paternal depression on children's development.
The effects of early paternal depression on children's development.
Med J Aust. 2011 Dec 19 ;195(11-12):685-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: