Proc Natl Acad Sci U S A. 1990 Oct;87(19):7517-21.

Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

Rock KL, Rothstein LE, Gamble SR, Benacerraf B.

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Division of Lymphocyte Biology, Dana-Farber Cancer Institute, Boston, MA 02115.

Abstract

T lymphocytes recognize endogenously produced antigenic peptides in association with major histocompatibility complex (MHC)-encoded molecules. Peptides from the extracellular fluid can be displayed in association with class I and class II MHC molecules. Here we report that mature Kb class I MHC molecules bind peptides upon dissociation and reassociation of their light chain. Intact Kb heterodimers, unlike class II MHC molecules, are relatively unreceptive to binding peptides. This property may maintain segregation of class I and class II MHC-restricted peptides and has implications for the use of peptides as vaccines.

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Presentation of exogenous antigen with class I major histocompatibility complex molecules. [Science. 1990]
Presentation of exogenous antigen with class I major histocompatibility complex molecules.
Rock KL, Gamble S, Rothstein L. Science. 1990 Aug 24; 249(4971):918-21.
Reassociation with beta 2-microglobulin is necessary for Db class I major histocompatibility complex binding of an exogenous influenza peptide. [Proc Natl Acad Sci U S A. 1991]
Reassociation with beta 2-microglobulin is necessary for Db class I major histocompatibility complex binding of an exogenous influenza peptide.
Rock KL, Gamble S, Rothstein L, Benacerraf B. Proc Natl Acad Sci U S A. 1991 Jan 1; 88(1):301-4.
Analysis of the association of peptides of optimal length to class I molecules on the surface of cells. [Proc Natl Acad Sci U S A. 1992]
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Review The biochemistry and cell biology of antigen presentation by MHC class I and class II molecules. Implications for development of combination vaccines. [Ann N Y Acad Sci. 1995]
Review The biochemistry and cell biology of antigen presentation by MHC class I and class II molecules. Implications for development of combination vaccines.
Germain RN. Ann N Y Acad Sci. 1995 May 31; 754:114-25.
Review Antigen presenting cells. [Immunol Res. 1989]
Review Antigen presenting cells.
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Cited by 18 PubMed Central articles

An in vitro study of the dynamic features of the major histocompatibility complex class I complex relevant to its role as a versatile peptide-receptive molecule. [Proc Natl Acad Sci U S A. 1997]
An in vitro study of the dynamic features of the major histocompatibility complex class I complex relevant to its role as a versatile peptide-receptive molecule.
Hörig H, Papadopoulos NJ, Vegh Z, Palmieri E, Angeletti RH, Nathenson SG. Proc Natl Acad Sci U S A. 1997 Dec 9; 94(25):13826-31.
Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells. [Proc Natl Acad Sci U S A. 1997]
Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells.
Day PM, Yewdell JW, Porgador A, Germain RN, Bennink JR. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8064-9.
Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced. [J Exp Med. 1996]
Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.
Boniface JJ, Lyons DS, Wettstein DA, Allbritton NL, Davis MM. J Exp Med. 1996 Jan 1; 183(1):119-26.

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