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Proteins. 1990;8(1):44-61.

Crystallographic refinement of human serum retinol binding protein at 2A resolution.

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  • 1Department of Molecular Biology, Biomedicum Centre, Uppsala, Sweden.


Human serum retinol binding protein (RBP) in complex with retinol has been crystallographically refined to an R-factor of 18.1% with 2A resolution data. The protein topology results in an anti-parallel beta-barrel that encapsulates the retinol ligand. A detailed description of the protein and the binding site is provided. Our structural work has helped to define a family of proteins, many of which are carrier proteins for smaller ligand molecules. We describe the structural basis for the conservation of sequence within the family.

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