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    J Virol. 2012 Feb;86(4):2366-70. Epub 2011 Dec 14.

    Comparative analysis of transforming properties of E6 and E7 from different beta human papillomavirus types.

    Cornet I, Bouvard V, Campo MS, Thomas M, Banks L, Gissmann L, Lamartine J, Sylla BS, Accardi R, Tommasino M.

    Source

    IARC, Lyon, France.

    Abstract

    The cutaneous beta human papillomavirus (beta HPV) types appear to be involved in skin carcinogenesis. However, only a few beta HPVs have been investigated so far. Here, we compared the properties of E6 and E7 oncoproteins from six uncharacterized beta HPVs (14, 22, 23, 24, 36, 49). Only HPV49 E6 and E7 immortalized primary human keratinocytes and efficiently deregulated the p53 and pRb pathways. Furthermore, HPV49 E6, similarly to E6 from the oncogenic HPV16, promoted p53 degradation.

    PMID:
    22171257
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3302372
    [Available on 2012/8/1]

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