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Physiology (Bethesda). 2011 Dec;26(6):412-23. doi: 10.1152/physiol.00032.2011.

Social regulation of gene expression in the hypothalamic-pituitary-gonadal axis.

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  • 1Department of Biology, Stanford University, Stanford, California, USA.


Reproduction is a critically important event in every animals' life and in all vertebrates is controlled by the brain via the hypothalamic-pituitary-gonadal (HPG) axis. In many species, this axis, and hence reproductive fitness, can be profoundly influenced by the social environment. Here, we review how the reception of information in a social context causes genomic changes at each level of the HPG axis.

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