Source
Department of Thoracic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan; Department of Thoracic and Cardiovascular Surgery, Kansai Rosai Hospital, Hyogo, Japan. taiwata@med.osaka-cu.ac.jp.
Abstract
BACKGROUND AND OBJECTIVES:
We investigated various tumor markers in patients with surgically treated small cell lung cancer (SCLC) to identify the markers closely correlated to pathological staging and to predict survival by retrospective analyses.
METHODS:
Reviewing database records between 1990 and 2007 revealed 36 patients with SCLC, that were grouped according to clinical and pathological stages. Receiver operating characteristic (ROC) curves were calculated for serum levels of various tumor makers to predict the pathological stage. The cut-off value was calculated from the ROC curve of the significant marker. Survival in patient groups divided by the new cut-off value was calculated.
RESULTS:
Serum levels of various tumor makers were not significantly different between the pathological stage groups, except for serum sialyl Lewis X (SLX). ROC curve of SLX was significantly correlated to pathological stages (P = 0.0136). The calculated SLX cut-off value was 25.1 U/ml, with 80% sensitivity and 70% specificity. Five-year survival of patients selected by this new cut-off was 82.5%, whereas that with the standard cut-off (38.0 U/ml) was 55.9%.
CONCLUSIONS:
Serum SLX values were associated with pathological stage and survival after surgery in SCLC patients. J. Surg. Oncol. 2012; 105:818-824. © 2011 Wiley Periodicals, Inc.
Copyright © 2011 Wiley Periodicals, Inc.