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Comp Immunol Microbiol Infect Dis. 2012 May;35(3):219-26. doi: 10.1016/j.cimid.2011.11.003. Epub 2011 Dec 14.

BCG vaccination of neonatal calves: potential roles for innate immune cells in the induction of protective immunity.

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  • 1Institute for Animal Health, Compton, Newbury, Berkshire RG207NN, United Kingdom.


Bovine tuberculosis is a disease of increasing incidence in the UK causing major economic losses and with significant impact on bovine and, potentially human health: the causative agent Mycobacterium bovis is a zoonotic pathogen. Neonatal vaccination with the attenuated M. bovis Bacille Calmette Guerin (BCG) vaccine confers a significant degree of protection in cattle, and is a widely used control strategy for human TB. The adaptive immune system is relatively immature in neonates and increased numbers of innate effector cells present in young animals and human infants may compensate for this, enabling effective immune responses to vaccination. Natural killer cells and subsets of γδ TCR+ T lymphocytes secrete high levels of interferon gamma and can interact with antigen presenting cells to promote both innate and adaptive immune responses. These cell populations may be pivotal in determining immune bias following neonatal vaccination with BCG.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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