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Chembiochem. 2011 Dec 16;12(18):2740-4. doi: 10.1002/cbic.201100569. Epub 2011 Nov 7.

Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.

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  • 1Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany.

Abstract

Gas-phase protein separation by ion mobility: With its ability to separate the Parkinson's disease protein α-synuclein and its autoproteolytic products-despite the small concentrations of the latter-ion-mobility MS has enabled the characterization of intermediate fragments in in vitro oligomerization-aggregation. In particular, a possible key fragment, the highly aggregating C-terminal fragment, αSyn(72-140), has been revealed.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
22162214
[PubMed - indexed for MEDLINE]
PMCID:
PMC3461308
Free PMC Article
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