Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neural Transm (Vienna). 2012 Jun;119(6):701-7. doi: 10.1007/s00702-011-0747-x. Epub 2011 Dec 11.

Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.

Author information

  • 1Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Box 5765, Ann Arbor, MI 48109-2700, USA.

Abstract

Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk