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J Neural Transm (Vienna). 2012 Jun;119(6):701-7. doi: 10.1007/s00702-011-0747-x. Epub 2011 Dec 11.

Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.

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  • 1Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Box 5765, Ann Arbor, MI 48109-2700, USA.


Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.

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