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Hematology Am Soc Hematol Educ Program. 2011;2011:405-6. doi: 10.1182/asheducation-2011.1.405.

What is the evidence for the use of immunomodulatory agents to eradicate inhibitory antibodies in patients with severe hemophilia a who have previously failed to respond to immune tolerance induction?

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  • 1Wayne State University and Children's Hospital of Michigan, Detroit, MI 48201, USA. mcallagh@med.wayne.edu

Abstract

An 18-year-old man has severe hemophilia A that has been complicated by a high-titer inhibitory antibody (peak 170 BU/mL). He had previously failed a trial of immune tolerance induction (ITI) using daily high-dose (100 units/kg/d) factor VIII (FVIII) for 20 months and would like to know if immunomodulatory agents, with or without another course of ITI, might eradicate the inhibitor.

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