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J Neurosci. 2011 Dec 7;31(49):18180-4. doi: 10.1523/JNEUROSCI.4960-11.2011.

Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant.

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  • 1Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, D-11017 Berlin, Germany.


Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.

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