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Pediatrics. 2012 Jan;129(1):e199-203. doi: 10.1542/peds.2010-2739. Epub 2011 Dec 12.

Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review.

Author information

  • 1Department of Pediatric Immunology and Hematology, Necker Hospital, AP-HP, Paris, France. Sandrine.leroy@pasteur.fr

Abstract

Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.

PMID:
22157133
[PubMed - indexed for MEDLINE]
PMCID:
PMC3273364
Free PMC Article

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