Antimicrob Agents Chemother. 2012 Mar;56(3):1616-8. Epub 2011 Dec 12.

Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.

Belser JA, Sleeman K, Pearce MB, Katz JM, Gubareva LV, Tumpey TM.

Source

Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Abstract

The majority of human infections associated with H7 influenza viruses have resulted in ocular and not respiratory disease. While oseltamivir has been prescribed to individuals presenting with conjunctivitis following H7 virus exposure, it is unknown if oseltamivir inhibits virus replication in ocular tissue. We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues.

PMID:: 22155827; [PubMed - in process]
PMCID:: PMC3294944; [Available on 2012/9/1]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract. [J Virol. 2009]
Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract.
Belser JA, Wadford DA, Xu J, Katz JM, Tumpey TM. J Virol. 2009 Jul; 83(14):7075-84. Epub 2009 May 20.
Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans. [J Virol. 2007]
Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans.
Belser JA, Lu X, Maines TR, Smith C, Li Y, Donis RO, Katz JM, Tumpey TM. J Virol. 2007 Oct; 81(20):11139-47. Epub 2007 Aug 8.
Development of Eurasian H7N7/PR8 high growth reassortant virus for clinical evaluation as an inactivated pandemic influenza vaccine. [Vaccine. 2008]
Development of Eurasian H7N7/PR8 high growth reassortant virus for clinical evaluation as an inactivated pandemic influenza vaccine.
Jadhao SJ, Achenbach J, Swayne DE, Donis R, Cox N, Matsuoka Y. Vaccine. 2008 Mar 25; 26(14):1742-50. Epub 2008 Feb 13.
Review Influenza virus neuraminidase inhibitors. [Lancet. 2000]
Review Influenza virus neuraminidase inhibitors.
Gubareva LV, Kaiser L, Hayden FG. Lancet. 2000 Mar 4; 355(9206):827-35.
Review [Neuraminidase inhibitors and risk of H5N1 influenza]. [Ann Pharm Fr. 2007]
Review [Neuraminidase inhibitors and risk of H5N1 influenza].
Gras-Masse H, Willand N. Ann Pharm Fr. 2007 Jan; 65(1):50-7.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the oc...
Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.
Antimicrob Agents Chemother. 2012 Mar ;56(3):1616-8. Epub 2011 Dec 12 .

PubMed
Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-defi...
Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo.
Antiviral Res. 2012 Feb ;93(2):301-4. Epub 2011 Dec 4 .

PubMed
TB incidence in UK decreases for first time in two decades.
TB incidence in UK decreases for first time in two decades.
BMJ. 2011 Dec 9 ;343:d8033. doi: 10.1136/bmj.d8033.

PubMed
Why can't a woman be more like a man?
Why can't a woman be more like a man?
N Engl J Med. 1990 Oct 11 ;323(15):1064-5.

PubMed
Spatial memory is improved by aerobic and resistance exercise through divergent ...
Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms.
Neuroscience. 2012 Jan 27 ;202:309-17. Epub 2011 Dec 2 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.

Source

Abstract

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information