Warning: The NCBI web site requires JavaScript to function. more...

Sign in to NCBI

Result Filters

We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Cancer Lett. 2012 May 1;318(1):53-60. doi: 10.1016/j.canlet.2011.11.035. Epub 2011 Dec 6.

Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis.

Yeo AT, Porco JA Jr, Gilmore TD.

Source

Department of Biology, Boston University, Boston, MA 02215, USA.

Abstract

In this report, we investigated the effects of the natural product parthenolide on human B-lymphoma cell lines. We show that parthenolide inhibited NF-κB transcription factor c-Rel (REL). In addition, the sensitivity of several human B-lymphoma cell lines to parthenolide-induced apoptosis inversely correlated with their levels of anti-apoptosis protein Bcl-X(L). Furthermore, ectopic expression of Bcl-X(L) (but not Bcl-2) in two B-lymphoma cell lines decreased their sensitivity to parthenolide-induced apoptosis. Finally, over-expression of a transforming mutant of REL, which increased expression of endogenous Bcl-X(L), decreased the sensitivity of BJAB B-lymphoma cells to parthenolide-induced apoptosis. These results demonstrate that the NF-κB target gene products Bcl-X(L) and Bcl-2 can play different roles in protecting B-lymphoma cells from chemical-induced apoptosis.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:: 22155272; [PubMed - indexed for MEDLINE]
PMCID:: PMC3288124

Free PMC Article

Images from this publication.See all images (6)Free text

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Fig. 5

Fig 6

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Lymphoma - MedlinePlus Health Information

Supplemental Content

Icon for Elsevier Science

Icon for PubMed Central

Save items

loading

PubReader: A whole new way to read scientific literature at PubMed Central.

Related citations in PubMed

B-cell lymphoma-2 over-expression protects δ-elemene-induced apoptosis in human lung carcinoma mucoepidermoid cells via a nuclear factor kappa B-related pathway. [Biol Pharm Bull. 2011]
B-cell lymphoma-2 over-expression protects δ-elemene-induced apoptosis in human lung carcinoma mucoepidermoid cells via a nuclear factor kappa B-related pathway.
Xie CY, Yang W, Ying J, Ni QC, Pan XD, Dong JH, Li K, Wang XS. Biol Pharm Bull. 2011; 34(8):1279-86.
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. [Oncogene. 2000]
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.
Patel NM, Nozaki S, Shortle NH, Bhat-Nakshatri P, Newton TR, Rice S, Gelfanov V, Boswell SH, Goulet RJ Jr, Sledge GW Jr, et al. Oncogene. 2000 Aug 24; 19(36):4159-69.
Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. [J Immunol. 2003]
Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis.
Pham LV, Tamayo AT, Yoshimura LC, Lo P, Ford RJ. J Immunol. 2003 Jul 1; 171(1):88-95.
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. [EMBO J. 1996]
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.
Wu M, Lee H, Bellas RE, Schauer SL, Arsura M, Katz D, FitzGerald MJ, Rothstein TL, Sherr DH, Sonenshein GE. EMBO J. 1996 Sep 2; 15(17):4682-90.
Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53. [Clin Immunol. 1999]
Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.
Han SS, Chung ST, Robertson DA, Ranjan D, Bondada S. Clin Immunol. 1999 Nov; 93(2):152-61.

See reviews... See all...

Cited by 1 PubMed Central article

The Sensitivity of Diffuse Large B-Cell Lymphoma Cell Lines to Histone Deacetylase Inhibitor-Induced Apoptosis Is Modulated by BCL-2 Family Protein Activity. [PLoS One. 2013]
The Sensitivity of Diffuse Large B-Cell Lymphoma Cell Lines to Histone Deacetylase Inhibitor-Induced Apoptosis Is Modulated by BCL-2 Family Protein Activity.
Thompson RC, Vardinogiannis I, Gilmore TD. PLoS One. 2013; 8(5):e62822. Epub 2013 May 7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide...
Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis.
Cancer Lett. 2012 May 1 ;318(1):53-60. doi: 10.1016/j.canlet.2011.11.035. Epub 2011 Dec 6 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk