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Toxicology. 2012 Feb 6;292(1):1-12. doi: 10.1016/j.tox.2011.11.012. Epub 2011 Nov 28.

The metabolism of steroids, toxins and drugs by 11β-hydroxysteroid dehydrogenase 1.

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  • 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical College, Wenzhou, Zhejiang 325000, China.

Abstract

11β-Hydroxysteroid dehydrogenase isoform 1 (11β-HSD1) is a member of the alcohol short-chain family enzyme, and catalyzes the interconversion between active glucocorticoid cortisol (in human) and inactive cortisone. The redox ratio of NADP+/NADPH determines its direction with NADPH favoring its reductase activity and NADP+ favoring its oxidase activity. In many tissues such as the liver and lung, 11β-HSD1 behaves primarily as a reductase because of the intracellular enzyme coupling with hexose-6-phosphate dehydrogenase, which uses the NADP+ as cofactor to supply NADPH driving 11β-HSD1 to function as a reductase. 11β-HSD1 catalyzes the metabolism of 7- or 11-keto steroids as well as many toxins and drugs. Some steroids, drugs and toxins are metabolically activated. The present review discusses the steroid, drug and toxin metabolism by 11β-HSD1.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
22154985
[PubMed - indexed for MEDLINE]
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