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Gen Hosp Psychiatry. 2012 Sep-Oct;34(5):578.e5-6. doi: 10.1016/j.genhosppsych.2011.11.001. Epub 2011 Dec 9.

Oral-paliperidone-induced tardive dyskinesia: a case report.

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  • 1Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.



Tardive dyskinesia (TD) is generally considered the most severe extrapyramidal sequelae of antipsychotic treatments.


Case report.


We present a 20-year-old woman with previous treatment of risperidone 6-7 mg daily for approximately 4 years. She developed TD 2 years later after switching to paliperidone 9 mg daily. To the best of our knowledge, she is the first case report of having direct paliperidone-induced TD. Immediate treatments including paliperidone dose reduction to 6 mg daily, clonazepam 1.5 mg daily and trihexyphenidyl 2 mg daily were performed for 1 month, and her symptoms were relieved eventually after switching to clozapine 75 mg daily.


Although second-generation antipsychotics such as paliperidone are considered to have a lowered risk of developing TD, this case could bring awareness to clinicians of the possibility of TD with the use of any antipsychotics.

Copyright © 2012 Elsevier Inc. All rights reserved.

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