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J Neuroimmunol. 2012 Jan 18;242(1-2):52-9. doi: 10.1016/j.jneuroim.2011.11.005. Epub 2011 Dec 6.

Immune profiling of Alzheimer patients.

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  • 1Department of Internal Medicine II, Center for Medical Research, University of Tübingen, Tübingen Aging and Tumor Immunology group, Waldhörnlestr. 22, 72072 Tübingen, Germany. mariavaleria.pellicano@uni-tuebingen.de


Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease.

Copyright © 2011 Elsevier B.V. All rights reserved.

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